Talk 1: 12 horas día 4 de octubre
Conferenciante: Edoardo Saccenti, Associate Professor. Laboratory of
Systems and Synthetic Biology, Wageningen University & Research, the
Netherlands
Título: Multivariate experimental errors in Principal Component
Analysis: from correlations to loadings
Abstract:
Multivariate measurement errors are ubiquitous in all experimental
sciences. Depending on the experimental platform used to acquire data,
diverse types of errors are introduced, amounting to an admixture of
additive and multiplicative error components that can be uncorrelated or
correlated. In this talk I will review how experimental error affect
correlations, the building blocks of multivariate statistical methods,
and how this connect to the recovery of the subspace with Principal
Component Analysis (PCA) as obtained by using numerical simulations. I
will how show different error characteristics (variance, correlation,
correlation structure), loading structures and data distributions
influence the accuracy to estimate an error-free (true) subspace from
sampled data with PCA.
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Talk 2: 12:45 horas día 4 de octubre
Conferenciante: Age K. Smilde. Emeritus-Professor of Biosystem Data
Analysis, Swammerdam Institute for Life Sciences, University of
Amsterdam and professor of Computational Systems Biology at the
Department of Plant and Environmental Sciences at the University of
Copenhagen.
Título: Multidimensional Latent Path Models
Abstract:
In many cases in the life sciences we are confronted with measurements
performed on a biological system that can be arranged in multiple data
sets pertaining to different entities being measured, such as
metabolites, proteins, gene-expressions, microbiome compositions.
Traditionally such multiset data has been analyzed by multiblock or
multiset methods from chemometrics and psychometrics. Such an analysis
can be supervised, _e.g_., for predicting an outcome, or unsupervised,
_e.g._, exploratory analysis. Both types of analyses ignore the topology
of the individual data blocks, _i.e._, the way in which these individual
data blocks can be or must be arranged. In the social sciences methods
have emerged combining factor analysis with structural equation models
resulting in so-called latent path models, such as PLS-Path Modeling,
that deal with such topology. These latent path models usually assume
one latent variable per data block which is not sufficient for
high-dimensional life science data. In this talk, I will discuss how
this can be generalized to more than one latent variable per block. This
is not trivial and I will discuss methods, algorithms and interpretation
of such models. I will touch upon the topic of causality and will give
an example from the field of plant sciences.